RNA preprints: W28/2018

Scoring of pathogenic non-coding variants in Mendelian diseases through supervised learning on ancient, recent and ongoing purifying selection signals in human. Barthelemy Caron, Yufei Luo, Antonio Rausell

Fast and interpretable alternative splicing and differential gene-level expression analysis using transcriptome segmentation with Yanagi. Mohamed K Gunady, Steve Mount, Hector Corrada Bravo

Single-cell isoform RNA sequencing (ScISOr-Seq) across thousands of cells reveals isoforms of cerebellar cell types. Ishaan Gupta, Paul G Collier, Bettina Haase, Ahmed Mahfouz, Anoushka Joglekar, Taylor Floyd, Frank Koopmans, Ben Barres, August B Smit, Steven Sloan, Wenjie Luo, Olivier Fedrigo, M Elizabeth Ross, Hagen U Tilgner

Molecular simulations of the monovalent-ion dependent Folding Thermodynamics of RNA. Dave Thirumalai, Natalia A Denesyuk

Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia. Alva Rani James, Michael P Schroeder, Martin Neumann, Lorenz Bastian, Cornelia Eckert, Nicola Gökbuget, Jutta Ortiz Tanchez, Cornelia Schlee, Konstandina Isaakidis, Stefan Schwartz, Thomas Burmeister, Arend von Stackelberg, Michael A Rieger, Stefanie Göllner, Martin Horstman, Martin Schrappe, Renate Kirschner-Schwabe, Monika Brüggemann, Carsten Müller-Tidow, Hubert Serve, Altuna Akalin, Claudia D. Baldus

Spatial organization of single mRNPs at different stages of the gene expression pathway. Srivathsan Adivarahan, Nathan Livingston, Beth Nicholson, Samir Rahman, Bin Wu, Olivia Rissland, Daniel Zenklusen

Changes in neuronal immunofluorescence in the C- versus N-terminal domains of hnRNP H following D1 dopamine receptor activation. Qiu T Ruan, Neema Yazdani, Jacob A Beierle, Kathryn M Hixson, Kristen E Hokenson, Daniel J Apicco, Kimberly Luttik, Karen Zheng, Brandon F Maziuk, Peter EA Ash, Karen Szumlinski, Shelley Russek, Benjamin Wolozin, Camron D Bryant

Selective axonal translation of prenylated Cdc42 mRNA isoform supports axon growth. Seung Joon Lee, Amar N Kar, Riki Kawaguchi, Priyanka Patel, Pabitra K Sahoo, Byron Aguilar, Kelsey D Lanz, Caylee McCain, Giovanni Coppola, Qun Lu, Jeffery L. Twiss

Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes. Thasni Karedath, Ikhlak Ahmed, Wafaa Al Ameri, Fatima Al-Dasim, Simeon S Andrews, Samson Samuel, Iman K Al Azwani, Yasmin Ali Mohamoud, Arash Rafii, Joel A Malek

MicroRNA miR-7 and miR-17-92 in POMC neurons are associated with sex-specific regulation of diet-induced obesity. Tao Sun, Yanxia Gao, Jiaheng Li, Zhen Zhang, Ruihan Zhang, Andrew Pollock

Reconstitution of mammalian Cleavage Factor II involved in 3′ processing of mRNA precursors. Peter Schaefer, Christian Tueting, Lars Schoenemann, Uwe Kuehn, Thomas Treiber, Nora Treiber, Christian Ihling, Anne Graber, Walter Keller, Gunter Meister, Andrea Sinz, Elmar Wahle

mRNP architecture in translating and stress conditions reveals an ordered pathway of mRNP compaction. Anthony Khong, Roy Parker

Structural differences between pri-miRNA paralogs promotes alternative Drosha cleavage and expands target repertoires. Xavier Bofill De Ros, Wojciech K Kasprzak, Yuba Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tie-Juan Shao, Bruce A Shapiro, Yun-Xing Wang, Shuo Gu

The expanded universe of prokaryotic Argonaute proteins. Sergei Ryazansky, Andrey Kulbachinskiy, Alexei Aravin

Processivity, velocity and universal characteristics of nucleic acid unwinding by helicases. Shaon Chakrabarti, Christopher Jarzynski, D. Thirumalai

Cicada endosymbionts have tRNAs that are correctly processed despite having genomes that do not encode all of the tRNA processing machinery. James T Van Leuven, Meng Mao, Gordon M Bennett, John McCutcheon

Alzheimer’s disease risk SNPs show no strong effect on miRNA expression in human lymphoblastoid cell lines. Inken Wohlers, Colin Schulz, Fabian Kilpert, Lars Bertram

Regulating prospero mRNA Stability Determines When Neural Stem Cells Stop Dividing. Lu Yang, Tamsin J. Samuels, Yoav Arava, Francesca Robertson, Aino I. Järvelin, Ching-Po Yang, Tzumin Lee, David Ish-Horowicz, Ilan Davis

The role of Aβ circRNA in Alzheimer′s disease: alternative mechanism of Aβ biogenesis from Aβ circRNA translation. Dingding Mo, Di Cui, Xinping Li

Enhancing microRNA activity through increased endosomal release mediated by nigericin. Esteban A Orellana, Loganathan Rangasamy, Srinivasarao Tenneti, Ahmed M Abdelaal, Philip S. Low, Andrea L Kasinski

Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using genome-wide analyses. Inken Wohlers, Lars Bertram, Christina Lill

Model-based analysis of positive selection significantly expands the list of cancer driver genes, including RNA methyltransferases. Siming Zhao, Jun Liu, Pranav Nanga, Yuwen Liu, Ercument Cicek, Nicholas Knoblauch, Chuan He, Matthew Stephens, Xin He

miR-263b controls circadian rhythms and structural plasticity of small ventral lateral neurons by inhibition of Beadex. Xiaoge Nian, Wenfeng Chen, Weiwei Bai, Zhangwu Zhao, Yong Zhang

Posttranscriptional regulation of intestinal epithelial cell repair by RNA binding protein IMP1. Priya Chatterji, Kelly A Whelan, Sarah F Andres, Fernando Cid Samper, Lauren A Simon, Rei Mizuno, Emma T Lundsmith, David S.M Lee, Shun Liang, H.R. Sagara Wijeratne, Stefanie Marti, Lillian Chau, Patrick A Williams, Veronique Giroux, Benjamin J Wilkins, Gary D Wu, Premal Shah, Gian Gaetano Tartaglia, Kathryn E Hamilton

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